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Miconazole Nitrate is an antifungal API (Active Pharmaceutical Ingredient) used in antifungal creams and lotions.
Miconazole Nitrate USP-43
Miconazole Nitrate USP-43 is a high-purity pharmaceutical active ingredient (API) belonging to the imidazole class of antifungal agents. It is widely used in the formulation of topical and mucosal antifungal medications for the treatment of dermatological and yeast infections.
This material conforms to USP-43 specifications, making it suitable for use in regulated pharmaceutical manufacturing environments and compounding applications. It is micronized to provide better dispersion, smoother texture, and improved bioavailability in topical systems.
Miconazole Nitrate exhibits broad-spectrum antifungal activity, targeting both dermatophytes and yeasts by disrupting fungal cell membrane synthesis.
Key Applications
Pharmaceutical Formulations
- Athlete’s foot (tinea pedis) creams and sprays
- Ringworm (tinea corporis) treatments
- Jock itch (tinea cruris) formulations
- Vaginal antifungal creams and suppositories
- Oral antifungal gels (e.g., for thrush)
Compounding Pharmacy Use
- Custom antifungal creams and gels
- Combination dermatological formulations
Personal Care & Medicated Cosmetics
- Antimicrobial creams
- Medicated skincare products
Veterinary Applications
- Treatment of fungal infections in animals
Research & Development
- Antifungal formulation development
- Academic and pharmaceutical research
Mechanism of Action (Technical Insight)
Miconazole Nitrate inhibits the biosynthesis of ergosterol, a critical component of fungal cell membranes. This disruption compromises membrane integrity, leading to leakage of cellular contents and fungal cell death.
This well-established mechanism contributes to:
- Broad-spectrum antifungal efficacy
- Reliable performance in topical formulations
- Proven clinical effectiveness
This product is ideal for:
- Pharmaceutical manufacturers (OTC and generic drug producers)
- Contract manufacturing organizations (CMOs/CDMOs)
- Compounding pharmacies
- Cosmetic and personal care manufacturers
- Veterinary product manufacturers
- Universities and research laboratories
- Chemical distributors and resellers
Product Specifications
| Product Name | Miconazole Nitrate |
| CAS Number | 22832-87-7 |
| Grade | USP-43 |
| Chemical Class | Imidazole antifungal |
| Appearance | White to off-white crystalline powder |
| Assay (Typical) | 98.0% – 102.0% (USP range) |
| Solubility | Slightly soluble in water; soluble in organic solvents such as ethanol, propylene glycol and DMSO |
| Molecular Formula | C₁₈H₁₄Cl₄N₂O·HNO₃ |
| Particle size | D90 = 10µm |
Quality & Compliance
- Manufactured to USP-43 standards
- Suitable for regulated pharmaceutical applications
- Consistent batch-to-batch quality
Available Documentation:
Certificate of Analysis (CoA)
Safety Data Sheet (SDS)
Technical Data Sheet (TDS)
Packaging Options
Original product (Made in China) comes in 25 kg fiber drums. We repackage and offer smaller quantities to support Research and Development market:
Education and small R&D Quantities: 5 g, 25 g
Large R&D Quantities: 1 kg, 10 kg
Bulk Supply for drug manufacturing: 25 kg fiber drums
Custom packaging and private labeling available upon request for educational and research market.
Formulation Considerations
Miconazole Nitrate is commonly used in:
- Oil-in-water creams
- Gels and lotions
- Suppositories and vaginal formulations
Key formulation notes:
- Often combined with solvents such as propylene glycol
- Compatible with common emulsifiers and thickening agents
- Particle size may impact dispersion and bioavailability
Why Buy From Chemical Store?
- Reliable supply of pharmaceutical-grade materials
- Flexible packaging for research and educational market
- Technical understanding of formulation applications
- Responsive support for documentation and compliance needs
- Ideal for both established manufacturers and small-scale developers
Related Products
To support antifungal formulation development, consider:
- Carbomers (gel base thickening agents)
- Emulsifiers (cream formulations)
- Propylene glycol (solvent and penetration enhancer)
- Preservatives and stabilizers
Storage & Handling
- Store in a cool, dry, well-ventilated area
- Protect from moisture and direct sunlight
- Keep container tightly closed
Refer to the SDS for complete safety and handling information.
Regulatory & Usage Notice
This product is intended for:
- Pharmaceutical manufacturing
- Compounding and laboratory use
- Antifungal drug research
Not intended for direct consumer use.
Buyers are responsible for ensuring compliance with all applicable regulations in their jurisdiction.
Benzoic Acid, USP, FCC, Kosher, ACS Reagent, >99.5%
Benzoic Acid (C₆H₅COOH) is a high-purity compound (>99.5%) widely used as an antimicrobial preservative in the food and beverage industry. Its potent antibacterial and antifungal properties, particularly effective at pH levels between 2.5 and 4.0, make it ideal for preventing spoilage in carbonated beverages and other acidic foods. Benzoic Acid is USP, FCC, Kosher, and ACS Reagent grade, ensuring its suitability for food-grade, industrial, and laboratory applications. With a molar mass of 122.12 and a melting point of 122.13°C, it is a reliable chemical for both practical and analytical uses. A Certificate of Analysis (COA) can be ordered for detailed specifications.
Product Specifications
| Chemical Name | Benzoic Acid |
| Chemical Formula | C₆H₅COOH |
| Purity | >99.5% |
| Molar Mass | 122.12 g/mol |
| Melting Point | 122.13°C |
| Applications | Food preservative, beverages, laboratory research |
| CAS Number | 65-85-0 |
Applications and Benefits:
- Preserves acidic foods and carbonated beverages
- Prevents bacterial and fungal spoilage
- Suitable for food, industrial, and lab use
- Conforms to USP, FCC, Kosher, and ACS Reagent standards
- COA available upon request
Caution:
Avoid inhalation and contact with skin or eyes. Use appropriate personal protective equipment. Store in a cool, dry place.
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