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Easily dispersed powder, modifies viscosity and rheology, nonionic agent.
Easily dispersed powder, modifies viscosity and rheology, nonionic thickening agent.
Miconazole Nitrate is an antifungal API (Active Pharmaceutical Ingredient) used in antifungal creams and lotions.
Hydroxyethyl Cellulose HEC 250 HHBR
HEC (Hydroxyethylcellulose) is a nonionic thickener and rheology modifier for water-based products. It is commonly used in detergents, cleaners, shampoos, conditioners, body washes, lotions, paints, coatings, adhesives, and other aqueous formulations requiring viscosity control and stable flow properties. This grade of HEC with designation 250 HHBR offers delayed hydration along with enhanced resistance to biological and chemical degradation. The rheology characteristics of the HHBR grade help provide stable viscosity performance in surfactant-based and industrial aqueous systems. A 1% preparation of HEC250HHBR in water typically produces a viscosity of approximately 3400 to 5500 cps. HEC250HHBR is an off-white granular powder that disperses and dissolves in cold or hot water to form smooth clear solutions with pseudoplastic flow behavior. Chemically, it is cellulose ether modified with hydroxyethyl groups to provide thickening, stabilization, water retention, suspension, and rheology control properties. For cold or room temperature preparation, continuous agitation for approximately 30 minutes is recommended to achieve full hydration and uniform viscosity development. HEC complies with applicable U.S. Food and Drug Administration requirements for certain food-contact surface applications as specified in the Code of Federal Regulations, Title 21. This grade of HEC does not comply with USP/FCC requirements for pharmaceutical applications. Perfect for detergent formulators, coating manufacturers, adhesive producers, industrial manufacturers, and personal care developers.
Product Specifications
| Product Name | Hydroxyethyl Cellulose HEC 250 HHBR |
| CAS Number | 9004-62-0 |
| CAS Name | Cellulose, 2-hydroxyethyl ether |
| Appearance | Off-white granular powder |
| Moisture Content | 5% Max |
| pH of Solution | 6.0 to 8.5 |
| Particle Size | Passes U.S. Mesh 325 |
| Viscosity | 3400 to 5500 cps, 1% solution |
| Hydration | Delayed hydration grade |
| Preparation | Continuous agitation for approximately 30 minutes is recommended for cold or room temperature preparation. |
Applications and Benefits:
- Nonionic thickener and rheology modifier for water-based products.
- Provides viscosity control and stable flow properties in aqueous formulations.
- Delayed hydration grade for controlled dispersion and hydration.
- Enhanced resistance to biological and chemical degradation.
- Stable viscosity performance in surfactant-based and industrial aqueous systems.
- Disperses and dissolves in cold or hot water to form smooth clear solutions.
- Provides pseudoplastic flow behavior.
- Supports thickening, stabilization, water retention, suspension, and rheology control.
- Compatible with many surfactants, polymers, salts, and formulation additives.
- Suitable for formulations exposed to microbial growth conditions or long-term storage instability.
- Used in detergents and household cleaners.
- Used in shampoos, conditioners, body washes, lotions, and personal care products.
- Used in water-based paints and coatings.
- Used in adhesives and latex systems.
- Used in industrial aqueous formulations and pigment dispersions.
- Suitable for detergent formulators, coating manufacturers, adhesive producers, industrial manufacturers, and personal care developers.
Caution:
This grade of HEC does not comply with USP/FCC requirements for pharmaceutical applications. Review applicable regulatory requirements before use. ADD SDS LINK HERE
Hydroxyethyl Cellulose HEC 250 HHBR
HEC (Hydroxyethylcellulose) is a thickener for water based products. The HEC allows you to modify rheology and build pleasing textures in shampoos, conditioners, body washes, hair colorants, creams and lotions, skin cleansers and many more.
This grade of HEC with designation 250 HHBR offer delayed hydration and superior resistance to biological and chemical degradation. A 1% preparation of HEC250 in water results a viscosity of about 3400 up to 5500 cps.
It is an off-white powder that is dispersed and dissolved in cold or hot water, to produce solutions of varying viscosities. Chemically, it is cellulose of short to very long chain that has been etherified to hydroxyethyl ether to achieve an optimum balance of properties. HEC250 is used as a viscosity and rheology modifier, protective colloid, water retention agent, stabilizer and suspending agent, particularly in those applications where a nonionic material is desired.
For cold or room temperature preparation a continuous stirring of at least 30 minutes is recommended to get a consistent and homogeneous viscosity.
Other properties are as follows:
Moisture content as packed, 5% Max
pH of solution: 6 up to 8.5
Particle size: Passes U.S. Mesh 325
Uses/ Applications:
HEC250HHBR hydroxyethylcellulose is a granular powder that dissolves in water to give clear smooth solutions, which exhibit a pseudoplastic flow behavior. At neutral pH and ambient temperature, it disperses in water without lump formation and provides easy dissolution. These solutions are unaffected by high concentration of soluble salts. Viscosity is little affected by mild acids and alkalies. Because of its nonionic character HEC has wide compatibility with other materials, such as emulsion polymers, natural and synthetic gums, emulsifiers, defoamers.
HEC is used as high efficiency nonionic thickener, water retension aid and rheology modifier in all types of water based paints and surface coatings, and in a variety of other aqueous industrial products. HEC250HHBR offers additional feature of superior storage stability when used under conditions that enhance microbial growth.
As a protective colloid and stabilizer HEC performs outstandingly in the emulsion and suspension polymerization of many vinyl polymers. Its unique combination of properties explains its use in pigment dispersion and in tile adhesives.
Regulatory Status:
HEC is in compliance with the requirements of the U.S. Food and Drug Administration for use in adhesives, resinous and polymeric coatings employed on food-contact surfaces of metal, paper or paperboard articles, and other suitable substances intended for use in food packaging as specified in the Code of Federal Regulations, Title 21, Sections 175.105, 175.300, 176.180, 177.1210. and 182.99.
This grade of HEC does not comply with USP/FCC for pharmaceutical applications.
CAS Number: 9004-62-0
CAS Name: Cellulose, 2-hydroxyethyl ether
Key Features
- Delayed hydration and superior stability
- Forms clear, smooth solutions
- Resistant to biological and chemical degradation
- Compatible with a wide range of materials
- Nonionic nature ideal for various applications
- Compliant with U.S. FDA for food-contact surfaces
Product Specifications
| Moisture Content | 5% Max |
| pH of Solution | 6 to 8.5 |
| Particle Size | Passes U.S. Mesh 325 |
| Viscosity (1% solution) | 3400 to 5500 cps |
| CAS Number | 9004-62-0 |
| CAS Name | Cellulose, 2-hydroxyethyl ether |
Perfect for cosmetic formulators, industrial manufacturers, adhesive producers, personal care developers, regulatory officers.
Miconazole Nitrate Micronized USP-43
Miconazole Nitrate Micronized USP-43 is a pharmaceutical-grade antifungal active ingredient (API) belonging to the imidazole class of antifungal compounds. It is commonly used in topical and mucosal antifungal formulations for pharmaceutical manufacturing, compounding, formulation development, and laboratory applications.
This material conforms to USP-43 specifications and is micronized to provide improved dispersion, enhanced uniformity, and smoother incorporation into topical and semi-solid formulations.
Miconazole Nitrate exhibits broad-spectrum antifungal activity against dermatophytes and yeasts through inhibition of ergosterol biosynthesis, an essential component of fungal cell membranes.
Key Applications
Pharmaceutical Formulations
- Topical antifungal creams and lotions
- Athlete’s foot (tinea pedis) formulations
- Ringworm (tinea corporis) products
- Jock itch (tinea cruris) products
- Vaginal antifungal creams and suppositories
- Antifungal sprays, powders, and gels
Compounding Pharmacy Use
- Custom antifungal creams and gels
- Combination dermatological formulations
Personal Care & Cosmeceutical Applications
- Medicated skincare products
- Antimicrobial topical formulations
Veterinary Applications
- Antifungal formulations for veterinary use
Research & Development
- Antifungal formulation development
- Pharmaceutical and academic research
Technical Information
Miconazole Nitrate inhibits the biosynthesis of ergosterol, an essential component of fungal cell membranes. This disruption compromises membrane integrity and contributes to antifungal activity in topical pharmaceutical systems.
Key Features:
- USP-43 pharmaceutical grade
- Micronized particle size for improved dispersion
- Consistent batch-to-batch quality
- Suitable for multiple topical dosage forms
- Broad-spectrum antifungal activity
This product is ideal for:
- Pharmaceutical manufacturers
- Contract manufacturing organizations (CMOs/CDMOs)
- Compounding pharmacies
- Cosmetic and personal care manufacturers
- Veterinary product manufacturers
- Universities and research laboratories
- Chemical distributors and resellers
Product Specifications
| Product Name | Miconazole Nitrate Micronized USP-43 |
| CAS Number | 22832-87-7 |
| EC Number | 245-256-6 |
| Grade | USP-43 |
| Chemical Class | Imidazole antifungal |
| Appearance | White to off-white crystalline powder |
| Assay | 98.0% – 102.0% (USP specification) |
| Typical Assay | 99.85% |
| Solubility | Slightly soluble in water; soluble in organic solvents such as ethanol, propylene glycol, PEG systems, and DMSO |
| Molecular Formula | C₁₈H₁₄Cl₄N₂O·HNO₃ |
| Molecular Weight | 479.14 g/mol |
| Particle Size | D90 = 10 µm |
| Melting Point | Approximately 178–182°C |
Quality & Compliance
- Manufactured in accordance with USP-43 specifications
- Packaged for pharmaceutical, compounding, and research applications
- Consistent batch-to-batch quality
Available Documentation:
Certificate of Analysis (CoA)
Safety Data Sheet (SDS)
Technical Data Sheet (TDS)
Packaging Options
Original material is manufactured in China and supplied in 25 kg fiber drums. Smaller repackaged quantities are available to support research, development, pilot-scale work, and formulation testing.
1oz – $49
1lb – $295
55lb (25 kg Drum) – $4495
Custom packaging and private labeling may be available upon request for research and industrial applications.
Formulation Considerations
Miconazole Nitrate is commonly incorporated into:
- Oil-in-water creams
- Gels and lotions
- Vaginal formulations
- Powder sprays and topical systems
Key formulation notes:
- Often pre-dispersed in propylene glycol or PEG systems
- Compatible with common emulsifiers and thickening agents
- Micronized particle size may improve formulation uniformity and dispersion
Why Buy From Chemical Store?
- Reliable supply of pharmaceutical-grade materials
- Flexible packaging for research and development applications
- Technical understanding of formulation applications
- Responsive support for documentation and compliance needs
- Ideal for both established manufacturers and small-scale developers
Related Products
To support antifungal formulation development, consider:
- Carbomers (gel base thickening agents)
- Emulsifiers (cream formulations)
- Propylene glycol (solvent and penetration enhancer)
- Preservatives and stabilizers
Storage & Handling
- Store in a cool, dry, well-ventilated area
- Protect from moisture and direct sunlight
- Keep container tightly closed
- Use appropriate PPE and avoid inhalation of dust
Refer to the SDS for complete safety and handling information.
Shipping Notice
Small quantities are typically shipped as non-regulated material for domestic ground transportation. Bulk quantities may require additional shipping review depending on destination, carrier requirements, and applicable regulations.
Regulatory & Usage Notice
This product is intended for:
- Pharmaceutical manufacturing
- Compounding applications
- Research and laboratory use
- Industrial formulation development
Not intended for direct consumer use or direct human consumption.
Buyers are responsible for ensuring compliance with all applicable local, state, federal, and international regulations regarding use, handling, formulation, labeling, and distribution.
Disclaimer
The information provided is believed to be accurate and reliable based on available supplier and internal documentation. Users are responsible for determining the suitability of this material for their specific application and for compliance with all applicable regulations.
